IT has cost $90 million and been six years in the making.
Hunter Medical Research Institute's new $90 million headquarters is less than a month from completion.
Staff are due to move in to the Rankin Park building, behind the John Hunter Hospital, from July 2.
The hub will initially accommodate about 400 researchers, with another 50 coming later.
Most are moving from the David Maddison building in Newcastle East and others from the John Hunter building.
Institute director Michael Nilsson said the new centre would be second to none.
"Modern medical research really demands top quality facilities to be able to, I mean the researchers need to perform at the highest level," he said.
Professor Nilsson said the laboratories and office space was built to the latest standards, with open space to promote interaction.
Researchers had expressed concern about lack of desk, storage and office space and insufficient parking.
Professor Nilsson said he was satisfied with the building and parking spaces would meet demand.
He said the new building would promote discussion among researchers and accommodate collaborations with national and international colleagues.
"It's the research hub we needed here in Newcastle and the Hunter," he said.
"We can now organise symposium, workshops, we can invite top delegations from around the world to come because we can now host them and we can be proud of this fantastic building."