Ben Simmons has scored 16 points and narrowly missed a triple-double as Philadelphia registered their fourth win in five NBA matches with victory over Portland.
The Australian had eight rebounds and nine assists in support of star 76ers centre Joel Embiid, who top scored with 28 points and 12 rebounds, in the 101-81 win at home on Wednesday.
Point-guard Simmons also contributed three steals and two blocks but was hurt by shooting at 47 per cent, his lowest accuracy and points tally in five matches.
Coming off a 21-point victory over Utah on Monday night when Simmons scored a career-high 27, the 76ers had the game's first 16 points and held a double-digit lead most of the game.
The Trail Blazers never got closer than eight points as Philadelphia had the best defensive outing of the season.
Meanwhile, LeBron James got stitches and then sliced Brooklyn open by himself as the Cleveland Cavaliers won 119-109 over the Brooklyn Nets.
James scored 23 of his 33 points in the fourth quarter and the Cavaliers won their sixth straight.
After he was accidentally headbutted by Brooklyn's Tyler Zeller in the third quarter, James went to the locker room, where Cleveland's medical staff closed the gash above his lip.
James said it wasn't his intent to take over after he came back out, it just happened.
"You can't force it," said James, who missed a wide-open dunk in the first half.
"You've got to let it come to you. It's times when you wish you can do it and sometimes the ball just doesn't go in. But I put a lot of work into my craft and I believe that every shot I take is going to go in."
The Miami Heat ended Boston's winning streak at 16 games after a 104-98 win against the NBA-leading Celtics.
Tim Hardaway Jr scored 38 points as the New York Knicks defeated the Toronto Raptors 108-100, the Charlotte Hornets overcame the Washington Wizards 129-124 in overtime and the Los Angeles Clippers beat the Atlanta Hawks 116-103.
The New Orleans Pelicans scored a 107-90 win over the San Antonio Spurs, Oklahoma City beat Golden State 108-91, Dallas had a 95-94 win against Memphis and Minnesota beat Orlando 124-118.