Trucks, car in Pacific Highway crash at Coolongolook

Two truck drivers have been flown to hospital with head injuries and multiple fractures after a serious accident near Taree on the NSW Mid North Coast.

A car towing a caravan was also involved in the crash on the Pacific Highway at Coolongolook, south of Taree, at about 11.15am on Thursday.

Four people are understood to have been travelling in the car but their condition is still unknown.

Emergency crews were confronted by a scene of crumpled vehicles and debris strewn along the highway near Willina Road. The two truck drivers were trapped in the cabs of their vehicles.

One of the trucks lay crumpled over a road barrier on its side. Two helicopters and multiple ambulances and fire engines descended on the accident site.

A spokesman for the NSW Ambulance Service said the two truck drivers both had fractures and head injuries.

One had been flown by helicopter to Westmead Hospital in Sydney, while the other has been airlifted to John Hunter Hospital in Newcastle.

"There scene is quite distressing. There is no information on the injuries or condition of the other four people [in the car]. There are multiple units and two choppers," he said.

The Pacific Highway has been closed to northbound traffic while two of three southbound lanes have been shut.

Police are diverting northbound traffic via the Lakes Way, apart from B-double trucks which have been advised to use the New England Highway.

Southbound traffic is heavy on the Pacific Highway because only one lane has remained open.