EMERGENCY services have been called to a two vehicle crash on Clarence Town Road south of Dungog.
The crash occurred about 6am Wednesday at Brookfield.
The Westpac Rescue Helicopter remained on scene at 7.30am as paramedics treated a woman for chest and head injuries.
She will be flown to John Hunter Hospital and is reportedly in a serious condition.
A second patient was taken by ambulance to John Hunter Hospital, no condition report is available at this time.
The road is expected to remain closed in both directions for some time. Use alternative route via Dunns Creek, Paterson onto Dungog Road.
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