Four-time defending champions Hamilton will have five players on debut for their first game of the year after what Hawks coach Scott Coleman described as a "disruptive" off-season.
Coming off the bye Passmore Oval newcomers hooker Reuben Gill, prop Michael Alifaalogo, flanker Liam Bowden, halfback Zac Sykes and winger Caileb Gerrard will have their maiden runs in the club's top XV when Hamilton meets the Bulls at Singleton on Saturday.
The likes of Steve Lamont (back) and Chris Ale (hamstring) are sidelined with injury, Seva Rokobaro (Merewether) and Kirisome Laulala (Lake Macquarie) changed allegiances while Ivan Walkling and Paddy Kilmurray both retired.
It means a new-look Hawks in 2019, starting with round two of the Newcastle Hunter Rugby Union premier 1 competition.
"We have five blokes making their first grade debuts this weekend," Coleman said.
"I can't remember that happening too much with us recently. It's been a really disruptive pre-season and our trial form was terrible.
"In saying that, we're looking forward to getting out there again and we know if it gets hard we need to play tight, play straight and do we what we know best by being patient with the ball."
History beckons for Hamilton in 2019, having equalled the premiership streak of The Waratahs between 1950 and 1953.
"We spoke about that at our boot camp, all the history, so it's not lost on us, " Coleman said.
"But there's only about five or six blokes that have been there the whole time, it's all about this group and this season. Everyone wants to win the comp at the start of the year."
Singleton have announced Dillon Rowney at No.13 to partner Rapine Mason in the centres while Jessy Kemp drops to fullback.
Elsewhere in Saturday's second-round encounters, Merewether have several changes to last week's XV that defeated Southern Beaches 87-0.
Most notably the Greens are missing No.8 Darcy Christie-Johnston, who faces surgery after breaking his fibia in the opening 10 minutes of round one, when they travel to Bill Strong Oval to play fellow first-up winners Nelson Bay.
Maitland tackle hosts University down centre Jye Estatheo, who faces an extended two month stint on the sideline because of a shoulder injury sustained on the weekend, while The Students welcome recruit Adrian Delore at fullback.
Walters Park sees Lake Macquarie home to Wanderers.
The Roos have Tevita Polamalu replacing Junior Osasa in the back-row while the visiting Two Blues have veteran Luke Sherwood at fly-half for Australian over 30s touch football representative Luke Simmons and winger Harrison Dal Molin on debut.
Southern Beaches have the bye.