Wests have fired an early warning shot in what Rosellas coach Matt Lantry described as "close to a complete performance".
The men in green and red scored at better than a point a minute for most of the first half before eventually defeating Lakes 46-6 in Sunday's Newcastle Rugby League season opener at Cahill Oval.
Wests started on fire and laid on seven tries in less than half an hour, starting with Mao Uta in the seventh minute and finishing with Chad O'Donnell's second in the 32nd minute.
The Rosellas, who last year missed the semi-finals for the first time since 1979, led 40-6 at the main break.
"It was a very good day out," Lantry said.
"If someone had of said you would win round one 46-6 I would have said you're kidding yourself.
"It was close to a complete performance. Our execution was the most pleasing."
Lantry was impressed with the display of five-eighth O'Donnell.
"He was absolutely enormous. Best on ground by far," the mentor said.
Mao Uta and Ryan Walker also nabbed doubles for Wests.
Felise Taufaao and Uti Baker were late replacements for Rosellas forwards Tama Koopu (shoulder) and Warren Schillings (ribs), who were both ruled out before kick-off.
Lakes centre Emmanuel Sithole suffered a possible torn pectoral.
Over at St John Oval on the same afternoon, defending premiers Souths accounted for Central 38-6 after leading 20-0 at half-time.
Butcher Boys centre Jermaine Ale (Achilles) could be sidelined after picking up a late injury.
On Saturday, Maitland beat hosts Cessnock 22-18 and Kurri defeated visitors Macquarie 28-12.
LADDER: Wests, Souths, Kurri, Maitland 2; Cessnock, Macquarie, Central, Lakes 0.